Neutrophil gelatinase-associated lipocalin (NGAL) in lupus nephritis and beyond.

ABSTRACT:

Objectives

To study neutrophil gelatinase-associated lipocalin (NGAL) levels in peripheral blood in SLE, and to propose a mechanism by which neutrophils secrete NGAL on stimulation with immune complexes (IC).

Methods

NGAL was measured by ELISA in two independent Swedish SLE cohorts acting as exploratory and validation cohort (n=124 and n=308, respectively), disease controls (n=38) and healthy controls (n=77). NGAL levels were measured in supernatant from IC-stimulated neutrophils in the presence or absence of a toll-like receptor 8 inhibitor (TLR8i).

Results

In the exploratory cohort, serum levels of NGAL were increased in patients with SLE as compared with healthy controls (p=0.021), and associated with histological-proven membranoproliferative lupus nephritis (LN) (

SUBMITTER: Barguil Macedo M 

PROVIDER: S-EPMC11751952 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature