Multigenerational family coaggregation study of obsessive-compulsive disorder and cardiometabolic disorders.

ABSTRACT:

Background

Obsessive-compulsive disorder (OCD) is associated with an increased risk of morbidity and mortality due to cardiometabolic disorders. Whether this association is driven by familial factors is unknown. This population-based family study explored the familial co-aggregation of OCD and cardiometabolic disorders.

Methods

We identified 6 049 717 individuals born in Sweden between 1950 and 2008, including 50 212 individuals with OCD, and followed them up to 2020. These individuals were linked to their mothers, fathers, full siblings, maternal and paternal half siblings, aunts, uncles and cousins. We estimated the risk of cardiovascular diseases (CVD) and metabolic disorders (including obesity, type 2 diabetes and hyperlipidaemia), comparing the relatives of probands wit

SUBMITTER: Holmberg A 

PROVIDER: S-EPMC11751958 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature