Unravelling the TCRβ repertoire: a key to unlocking the immunopathogenesis and precision medicine in SLE.

ABSTRACT:

Objectives

SLE is a multifaceted autoimmune disorder with a complex pathogenesis involving genetic, environmental and hormonal factors, which converge on immune dysregulation. The T cell receptor (TCR) repertoire's role in SLE has garnered significant interest due to its potential in both diagnostics and therapeutics. Our study aimed to delineate the variances in the TCRβ repertoire between patients with SLE and healthy individuals, correlating these differences with the severity and subtypes of SLE.

Methods

We conducted an analysis of blood samples from 50 treatment-naive patients with SLE and 50 healthy donors, employing RNA extraction, high-throughput sequencing and subsequent bioinformatics analysis.

Results

Our findings revealed significant alterations in TRBV an

SUBMITTER: Zeng L 

PROVIDER: S-EPMC11751993 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature