Association between early ondansetron use and the risk of sepsis in intensive care unit patients: a secondary data of the Medical Information Mart for Intensive Care IV database.

ABSTRACT:

Objective

This study planned to analyse the association between ondansetron use within 24 hours before intensive care unit (ICU) admission to within 48 hours after ICU admission and the risk of sepsis in ICU patients.

Design

A cohort study.

Setting and participants

Data of 65 366 participants in Medical Information Mart for Intensive Care IV from ICU in the Beth Israel Deaconess Medical Center.

Primary and secondary outcome measures

Sepsis was the primary outcome, which indicated patients with documented or suspected infection and acute change in total Sequential Organ Failure Assessment (SOFA) score ≥2 points. In-hospital mortality was the secondary outcome.

Results

There were 6737 patients with early ondansetron use. In total, 1646 patients suffered se

SUBMITTER: Liu X 

PROVIDER: S-EPMC11752024 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature