Associations of infection burden with Kawasaki disease in a population-based setting during 30 years.

ABSTRACT:

Objectives

The objective of this study was to investigate the role of infections in the pathogenesis of Kawasaki disease.

Methods

The investigation was a nationwide epidemiological case-control study, comprising all cases of Kawasaki disease diagnosed in Sweden 1987-2018. Controls were randomly sampled from the general population, matched on sex, age, and area of residency. Data on infections were obtained from the Swedish National Patient Register, which prospectively collects data on all Swedish residents. Infections were classified by organ system, infectious agent and by temporal proximity to Kawasaki disease diagnosis date. Prescription of antibiotics and infections in family members were also considered in separate analyses.

Results

The study comprised n=1774 (6

SUBMITTER: Mofors J 

PROVIDER: S-EPMC11752045 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature