Real-world efficacy of transfusion with liberal or restrictive strategy in traumatic brain injury.

ABSTRACT:

Objective

The short-term efficacy of red blood cell (RBC) transfusion among general traumatic brain injury (TBI) patients is unclear.

Methods

We used the MIMIC database to compare the efficacy of liberal (10 g/dL) versus conservative (7 g/dL) transfusion strategy in TBI patients. The outcomes were neurological progression (decrease of Glasgow coma scale (GCS) of at least 2 points) and death within 28 days of ICU admission. Each eligible individual was cloned and assigned each of the replicates to one of the treatment arm. The imbalance induced by informative censoring was adjusted by inverse probability weighting. The standardized, weighted pooled logistic regression with 500 bootstrap resampling was used to estimate the cumulative risk difference and 95% confidence interval

SUBMITTER: Cui LW 

PROVIDER: S-EPMC11752087 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature