In vivo evidence for cell body loss in cortical lesions in people with multiple sclerosis.

ABSTRACT:

Objective

To quantify alterations in soma and neurite density imaging measures within and surrounding cortical lesions in people with multiple sclerosis using in vivo high-gradient diffusion MRI.

Methods

In this cross-sectional study, 41 people with multiple sclerosis and 34 age- and sex-matched healthy controls underwent 3 T high-gradient diffusion MRI. Cortical lesions were segmented on artificial intelligence-enabled double inversion recovery images. "Inner" and "outer" perilesional layers were segmented as two expanding shells of 2 mm surrounding a cortical lesion. Intracellular, intra-neurite, and extracellular signal fractions and apparent soma radius were estimated in (peri)lesional and normal-appearing cortex.

Results

Cortical lesions were present in all peopl

SUBMITTER: Krijnen EA 

PROVIDER: S-EPMC11752088 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature