Cerebral hypoperfusion reduces tau accumulation.

ABSTRACT:

Objective

Alzheimer's disease (AD) often coexists with cerebrovascular diseases. However, the impact of cerebrovascular diseases such as stroke on AD pathology remains poorly understood.

Methods

This study examines the correlation between cerebrovascular diseases and AD pathology. The research was carried out using clinical and neuropathological data collected from the National Alzheimer's Coordinating Center (NACC) database and an animal model in which bilateral common carotid artery stenosis surgery was performed, following the injection of tau seeds into the brains of wild-type mice.

Results

Analysis of the NACC database suggests that clinical stroke history and lacunar infarcts are associated with lower neurofibrillary tangle pathology. An animal model demonstrate

SUBMITTER: Gheni G 

PROVIDER: S-EPMC11752094 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature