Cortical lesions impact cognitive decline in multiple sclerosis via volume loss of nonlesional cortex.

ABSTRACT:

Objective

To assess the interrelationship between cortical lesions and cortical thinning and volume loss in people with multiple sclerosis within cortical networks, and how this relates to future cognition.

Methods

In this longitudinal study, 230 people with multiple sclerosis and 60 healthy controls underwent 3 Tesla MRI at baseline and neuropsychological assessment at baseline and 5-year follow-up. Cortical regions (N = 212) were divided into seven functional networks. Regions were defined as either lesional or normal-appearing cortex based on presence of a cortical lesion on artificial intelligence-generated double inversion-recovery scans. Cortical volume and thickness were determined within lesional or normal-appearing cortex.

Results

Prevalence of at least one c

SUBMITTER: Krijnen EA 

PROVIDER: S-EPMC11752103 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature