Extracellular Vesicle-Encapsulated microRNAs and Respiratory Health Among American Indian Participants in the Strong Heart Study.

ABSTRACT:

Background

American Indian populations have experienced marked disparities in respiratory disease burden. Extracellular vesicle-encapsulated microRNAs (EV-miRNAs) are a novel class of biomarkers that may improve recognition of lung damage in indigenous populations in the United States.

Research question

Are plasma EV-miRNAs viable biomarkers of respiratory health in American Indian populations?

Study design and methods

The Strong Heart Study is a prospective cohort study that enrolled American Indian patients aged 45 to 74 years. EV-miRNA expression was measured in plasma (1993-1995). Respiratory health outcomes, including prebronchodilator FEV₁, FVC, and respiratory symptom burden, were ascertained in the same study visit. Club cell secretory protein (CC-1

SUBMITTER: Eckhardt CM 

PROVIDER: S-EPMC11752130 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature