Evaluating neurofilament light chain serum levels as a diagnostic marker for Lyme neuroborreliosis.

ABSTRACT:

Background

Serum neurofilament light chain (sNfL) is a biomarker for neuro-axonal injury.

Objectives

To assess sNfL's utility as a diagnostic marker for Lyme neuroborreliosis (LNB).

Methods

We compared serum and CSF NfL levels in LNB patients and age-matched controls. Age-adjusted NfL values were used in receiver operating characteristic (ROC) analysis.

Design

Retrospective cohort study.

Results

Eighty-six patients (30 LNB, 29 with-, and 27 without neurological disorders) were included. Compared to individuals without neurological disease, LNB patients showed increased serum (median (interquartile range, IQR): 36.3 pg/ml (19.3-112.0) vs 20 pg/ml (12.9-37.3), p < 0.001) and CSF NfL levels (median (IQR): 1000.0 pg/ml (286.0-6471.0) vs 182 pg/ml (99.

SUBMITTER: Hirzel C 

PROVIDER: S-EPMC11752212 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature