Evaluating agreement between individual nutrition randomised controlled trials and cohort studies - a meta-epidemiological study.

ABSTRACT:

Background

In nutrition research, randomised controlled trials (RCTs) and cohort studies provide complementary evidence. This meta-epidemiological study aims to evaluate the agreement of effect estimates from individual nutrition RCTs and cohort studies investigating a highly similar research question and to investigate determinants of disagreement.

Methods

MEDLINE, Epistemonikos, and the Cochrane Database of Systematic Reviews were searched from January 2010 to September 2021. We matched individual RCTs to cohort studies based on population, intervention/exposure, comparator, and outcome (PI/ECO) characteristics. Two reviewers independently extracted study characteristics and effect estimates and rated the risk of bias using RoB2 and ROBINS-E. Agreement of matched RCTs/coho

SUBMITTER: Stadelmaier J 

PROVIDER: S-EPMC11752614 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature