Unveiling cell-type-specific microRNA networks through alternative polyadenylation in glioblastoma.

ABSTRACT:

Background

Glioblastoma multiforme (GBM) is characterized by its cellular complexity, with a microenvironment consisting of diverse cell types, including oligodendrocyte precursor cells (OPCs) and neoplastic CD133 + radial glia-like cells. This study focuses on exploring the distinct cellular transitions in GBM, emphasizing the role of alternative polyadenylation (APA) in modulating microRNA-binding and post-transcriptional regulation.

Results

Our research identified unique APA profiles that signify the transitional phases between neoplastic cells and OPCs, underscoring the importance of APA in cellular identity and transformation in GBM. A significant finding was the disconnection between differential APA events and gene expression alterations, indicating that APA operates

SUBMITTER: Cihan M 

PROVIDER: S-EPMC11752630 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature