Brain microstructure alterations in subjective cognitive decline: a multi-component T2 relaxometry study.

ABSTRACT: Previous research has revealed patterns of brain atrophy in subjective cognitive decline, a potential preclinical stage of Alzheimer's disease. However, the involvement of myelin content and microstructural alterations in subjective cognitive decline has not previously been investigated. This study included three groups of participants recruited from the Compostela Aging Study project: 53 cognitively unimpaired adults, 16 individuals with subjective cognitive decline and hippocampal atrophy and 70 with subjective cognitive decline and no hippocampal atrophy. Group differences were analysed across five MRI biomarkers derived from multi-component T2 relaxometry, each sensitive to variations in cerebral composition and microstructural tissue integrity. Although no significant differences in m

SUBMITTER: Rivas-Fernandez MA 

PROVIDER: S-EPMC11752640 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature