Wnt/β-catenin Promotes Cementum Apposition in Periodontal Regeneration.

ABSTRACT: Regeneration of periodontal tissue, particularly the cementum-periodontal ligament (PDL)-bone complex, has long been challenging because the differentiation kinetics of cells and the molecular pathways contributing to the regeneration process are largely unknown. We aimed to evaluate the cell behavior and molecular pathways that contribute to periodontal tissue regeneration in vivo. We analyzed the process of periodontal tissue regeneration through subrenal capsule transplantation of immediately extracted molars in mice. We showed that the regenerated periodontal tissue in the subrenal capsule was morphologically comparable to the intact periodontal tissue, with increased cellular cementum thickness in the apical region. Cell tracing analysis revealed that the cells comprising the regenera

SUBMITTER: Ono Y 

PROVIDER: S-EPMC11752650 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature