Robust circulating microRNA signature for the diagnosis and early detection of pancreatobiliary cancer.

ABSTRACT:

Background

A new circulating biomarker superior to carbohydrate antigen 19-9 (CA19-9) is needed for diagnosing pancreatobiliary cancer (PBca). The aim of this study was to identify serum microRNA (miRNA) signatures comprising reproducible and disease-related miRNAs.

Methods

This multicenter study involved patients with treatment-naïve PBca and healthy participants. The optimized serum processing conditions were evaluated using t-distributed stochastic neighbor embedding (t-SNE) visualization. Serum miRNA candidates for disease association were selected using weighted gene coexpression network analysis (WGCNA). A miRNA signature combining multiple serum miRNAs was tested in exploratory, validation, and independent validation sets. The synthesis and secretion of diagnostic miR

SUBMITTER: Mitsunaga S 

PROVIDER: S-EPMC11752661 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature