Chronic restraint stress affects the diurnal rhythms of gut microbial composition and metabolism in a mouse model of depression.

ABSTRACT:

Background

Depression is a common mental disorder accompanied by gut microbiota dysbiosis, which disturbs the metabolism of the host. While diurnal oscillation of the intestinal microbiota is involved in regulating host metabolism, the characteristics of the intestinal microbial circadian rhythm in depression remain unknown. Our aim was to investigate the microbial circadian oscillation signature and related metabolic pathways in a mouse model with depression-like behaviours.

Methods

Chronic restraint stress (CRS) was used to induce depressive-like behaviours in C57BL/6J mice. The open field test (OFT) and forced swimming test (FST) were used to evaluate anxiety- and depressive-like behaviours in the control and CRS groups. Afterwards, faecal samples from the two groups were

SUBMITTER: Wang Y 

PROVIDER: S-EPMC11752688 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature