Single-cell profiling of SLC family transporters: uncovering the role of SLC7A1 in osteosarcoma.

ABSTRACT:

Background

Osteosarcoma is the most common malignant bone tumor in children and adolescents, characterized by high disability and mortality rates. Over the past three decades, therapeutic outcomes have plateaued, underscoring the critical need for innovative therapeutic targets. Solute carrier (SLC) family transporters have been implicated in the malignant progression of a variety of tumors, however, their specific role in osteosarcoma remains poorly understood.

Methods

The single-cell sequencing data from GSE152048 and GSE162454, along with RNA-seq from the TARGET and GSE21257 cohorts, were utilized for the analysis in this study. LASSO regression analysis was conducted to identify prognostic genes and construct an SLC-related prognostic signature. Survival analysis and ROC

SUBMITTER: Liao Y 

PROVIDER: S-EPMC11752724 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature