1,2,3-Triazole-tethered fluoroquinolone analogues with antibacterial potential: synthesis and in vitro cytotoxicity investigations.

ABSTRACT: The antibacterial efficacy of some newly developed bis- and C3-carboxylic moieties of fluoroquinolone-linked triazole conjugates was studied. Twenty compounds from two different series of triazoles were synthesized using click chemistry and evaluated for their antibacterial activity against a Gram-positive strain, i.e. Enterococcus faecalis (ATCC29212), and its clinical isolate and a Gram-negative bacterial strain, i.e. Escherichia coli (ATCC25922), and its clinical isolate. Among the compounds, 7, 9a, 9d, 9i, 10(a-d), and 10i showed excellent activity with MIC values of up to 6.25 μg mL^-1, whereas the control ciprofloxacin showed MIC values of up to 12.5 μg mL^-1 towards the various strains. Cytotoxicity was evaluated against Vero cells (kidney epithelia

SUBMITTER: Patel UK 

PROVIDER: S-EPMC11752755 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature