YHSeqY3000 panel captures all founding lineages in the Chinese paternal genomic diversity database.

ABSTRACT:

Background

The advancements in second-/third-generation sequencing technologies, alongside computational innovations, have significantly enhanced our understanding of the genomic structure of Y-chromosomes and their unique phylogenetic characteristics. These researches, despite the challenges posed by the lack of population-scale genomic databases, have the potential to revolutionize our approach to high-resolution, population-specific Y-chromosome panels and databases for anthropological and forensic applications.

Objectives

This study aimed to develop the highest-resolution Y-targeted sequencing panel, utilizing time-stamped, core phylogenetic informative mutations identified from high-coverage sequences in the YanHuang cohort. This panel is intended to provide a new tool

SUBMITTER: Wang M 

PROVIDER: S-EPMC11752814 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature