The relation of sarcopenia and disability in multiple sclerosis.

ABSTRACT:

Background

The relation of sarcopenia and disability in MS is unknown.

Objective

To investigate the relation of temporal muscle thickness (TMT) and disability.

Methods

A cohort of 132 people who presented with a clinically isolated syndrome (CIS) suggestive of MS at a mean age of 30.0 years, were prospectively followed clinically and with MRI over 30-years. TMT and expanded disability status scale (EDSS) were assessed at baseline, one- five- ten- fourteen- twenty- and thirty-year follow-up.

Results

At 30-years, 27 participants remained classified as having had a CIS, 34 converted to relapsing remitting MS, 26 to secondary progressive MS, and 16 had died due to MS. Using linear mixed effect models with subject nested in time, greater annualized TMT-thinning was

SUBMITTER: Haider L 

PROVIDER: S-EPMC11752834 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature