Antibodies directed against bacterial antigens in sera of Polish patients with primary biliary cholangitis.

ABSTRACT:

Background

Primary biliary cholangitis (PBC) is a cholestatic, autoimmune liver disease with the presence of characteristic autoantibodies. The aim of the work was to determine the level of antibodies directed against bacterial antigens: Chlamydia pneumoniae (anti-Cpn), Yersinia enterolitica (anti-Y.e), Helicobacter pylori (anti-Hp), Mycoplasma pneumoniae (anti- Mp.) and Escherichia coli (E.coli) in sera of PBC patients. We also performed in vitro studies on the impact of the bacterial peptides on the specific antigen-antibody binding.

Method

We screened 92 Polish PBC patients and sera samples from healthy donors and pathological controls. Autoantibodies and anti-bacterial antibodies were determined by com

SUBMITTER: Bauer A 

PROVIDER: S-EPMC11752878 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature