Prognostic value of immunosuppression scores in patients with esophageal squamous cell carcinoma: a multicenter study.

ABSTRACT:

Introduction

The prognostic impact of human leukocyte antigen-E (HLA-E) expression and the proportion of natural killer (NK) cells in esophageal squamous cell carcinoma (ESCC) was investigated.

Methods

This study retrospectively evaluated 397 ESCC patients across two centers. The cumulative incidence of recurrence (CIR) and the incidence of tumor-related death (CID) were analyzed in various groups. An immunosuppression score (ISS) was developed based on HLA-E expression and NK cell proportion. Differences between groups were adjusted using inverse probability treatment weighting (IPTW). The factors influencing cancer-specific survival (CSS) and recurrence-free survival (RFS) were also examined.

Results

Patients with low HLA-E expression had significantly higher five-y

SUBMITTER: Xu SJ 

PROVIDER: S-EPMC11752912 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature