Characteristics of transcriptome and chromatin accessibility in the peripheral blood after acute hypoxia exposure.

ABSTRACT:

Background

Human responses and acclimation to the environmental stresses of high altitude and low oxygen are multifaceted and regulated by multiple genes. However, the mechanism of how the body adjusts in a low-oxygen environment is not yet clear.

Results

Hence, we performed RNA sequencing (RNA-seq) and ATAC sequencing (ATAC-seq) to observe the changes of transcriptome and chromatin accessibility in the peripheral blood of eight individuals at 1 h post adaptation in a simulated plateau environment with 3500 m and 4500 m altitude, respectively. Differential expression analysis and the Boruta algorithm identified differentially expressed genes (DEGs) and differentially accessible regions (DARs) associated with hypoxia adaptation. Specifically, RNA-seq identified 93 and 7 DEGs

SUBMITTER: Zeng K 

PROVIDER: S-EPMC11752951 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature