Identification of Novel Genetic Loci Affecting Age at Onset of Parkinson's Disease: A Genome-wide Association Study.

ABSTRACT:

Background

The age at onset (AAO) of Parkinson's disease (PD) varies widely among individuals and significantly influences disease progression and prognosis. However, few genome-wide association studies (GWASs) have investigated genetic variants determining AAO, particularly in East Asian populations.

Objectives

To identify single-nucleotide polymorphisms (SNPs) affecting AAO of PD in Korean patients.

Methods

We conducted a GWAS on AAO of PD in 1048 Korean patients using sex-adjusted linear regression models. Additionally, we conducted downstream analyses of our primary GWAS results.

Results

rs2134545 demonstrated genome-wide significance (β = -2.459; standard error [SE] = 0.851; P = 1.898 × 10^-8) and is an intergenic SNP near the ALCAM gene associat

SUBMITTER: Hwang YS 

PROVIDER: S-EPMC11752982 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature