Insulin Resistance Is a Modifying Factor for Parkinson's Disease.

ABSTRACT:

Background

Parkinson's disease (PD) is the second most common, and the fastest-growing neurodegenerative disorder with unclear etiology in most cases. Therefore, the identification of non-genetic risk factors for PD pathology is crucial to develop effective preventative or therapeutic strategies. An increasing number of evidence suggests that central insulin resistance might have an essential role in PD pathology. Nevertheless, it is not clear whether insulin resistance arises from external factors/lifestyle, comorbidities such as type 2 diabetes or it can occur in a PD patient's brain independently from peripheral insulin resistance.

Objective

We aimed to investigate insulin resistance and its role in GBA1 mutation-associated PD pathogenesis and phenotype severity.

Metho

SUBMITTER: Zagare A 

PROVIDER: S-EPMC11752983 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature