Impaired Gait, Postural Instability, and Rigidity in Relation to CB1 Receptor Availability in Parkinson's Disease.

ABSTRACT:

Background

In Parkinson's disease (PD), postural instability and gait disorder (PIGD) symptoms are associated with a worse prognosis for an unknown reason.

Objective

The objective was to explore the relationship between cannabinoid receptor type 1 (CB1R) availability and motor symptoms in PD with [¹⁸F]FMPEP-d₂ positron emission tomography (PET).

Methods

Fifteen individuals with PD underwent [¹⁸F]FMPEP-d₂ PET to measure cerebral CB1R availability. The Unified Parkinson's Disease Rating Scale motor part (UPDRS-III) was used to evaluate the motor symptoms.

Results

A negative correlation was observed between [¹⁸F]FMPEP-d₂ V_T and PIGD score (P = 0.002) as well as rigidity subscore (P < 0.00

SUBMITTER: Ajalin R 

PROVIDER: S-EPMC11752992 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature