Non-invasive electron paramagnetic resonance imaging detects tumor redox imbalance induced by ferroptosis.

ABSTRACT: Targeting ferroptosis, cell death caused by the iron-dependent accumulation of lipid peroxides, and disruption of the redox balance are promising strategies in cancer therapy owing to the physiological characteristics of cancer cells. However, the detection of ferroptosis using in vivo imaging remains challenging. We previously reported that redox maps showing the reduction power per unit time of implanted tumor tissues via non-invasive redox imaging using a novel, compact, and portable electron paramagnetic resonance imaging (EPRI) device could be compared with tumor tissue sections. This study aimed to apply the EPRI technique to the in vivo detection of ferroptosis. Notably, redox maps reflecting changes in the redox status of tumors induced by the ferroptosis-inducing age

SUBMITTER: Kato K 

PROVIDER: S-EPMC11753017 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature