In vitro evaluation of anthelmintic activity of biocompatibile carbon quantum dot nanocomposite against egg and larval stages of equine strongyles.

ABSTRACT:

Background

Strongyle nematodes pose a major challenge in veterinary parasitology, causing significant economic losses in livestock due to resistance to conventional treatments. Current anthelmintics, like Ivermectin, often encounter resistance issues. This study aims to address these gaps by synthesizing Carbon Quantum Dots (CQDs) and Copper-Doped CQDs (Cu@CQDs) using glucose extract, and evaluating their nematicidal properties against strongyles in vitro. We assessed the nematicidal effects of CQDs and Cu@CQDs through larval feeding inhibition of first-stage larvae (L1), egg hatch inhibition (EHI), and the mobility and mortality of infectious larvae (L3s). Additionally, we conducted ultrastructural examinations of eggs and larvae and evaluated oxidative/nitrosative stress indicato

SUBMITTER: Fakheri A 

PROVIDER: S-EPMC11753018 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature