ClearFinder: a Python GUI for annotating cells in cleared mouse brain.

ABSTRACT:

Background

Tissue clearing combined with light-sheet microscopy is gaining popularity among neuroscientists interested in unbiased assessment of their samples in 3D volume. However, the analysis of such data remains a challenge. ClearMap and CellFinder are tools for analyzing neuronal activity maps in an intact volume of cleared mouse brains. However, these tools lack a user interface, restricting accessibility primarily to scientists proficient in advanced Python programming. The application presented here aims to bridge this gap and make data analysis accessible to a wider scientific community.

Results

We developed an easy-to-adopt graphical user interface for cell quantification and group analysis of whole cleared adult mouse brains. Fundamental statistical analysis, such

SUBMITTER: Pastore S 

PROVIDER: S-EPMC11753021 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature