The role of 1-Deoxysphingolipids and Polyamines in the pathogenesis of placental syndrome.

ABSTRACT:

Background

Placental syndrome, mainly composed of preeclampsia and fetal growth restriction, has an impact on the health of mother and baby dyads. While impaired placentation is central to their pathophysiology, the underlying molecular mechanisms remain incompletely understood. This study investigates the association between placental syndrome and metabolic alterations in 1-deoxysphingolipids (1-deoxySLs) and polyamines, along with their regulatory enzymes.

Methods

This prospective case-control study involved 26 healthy pregnant women and 17 with placental syndrome. Blood samples were collected from maternal, uterine venous, and umbilical cord veins. Levels of 1-deoxySL, spermine, and spermidine, as well as related enzymes of polyamine metabolism such as ornithine decarboxy

SUBMITTER: Guleroglu FY 

PROVIDER: S-EPMC11753022 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature