Cancer incidence and the influence of immunosuppressive agents in Korean patients with systemic lupus erythematosus: a retrospective cohort study.

ABSTRACT:

Background

To investigate cancer incidence and the potential influence of immunosuppressive agents in Korean systemic lupus erythematosus (SLE) patients.

Methods

We conducted a retrospective analysis utilizing data from the Korea Healthcare Bigdata Linked Platform, which integrated the National Central Cancer Registry and National Health Insurance Service databases covering the period 2008-2017. Incidence rates (IRs) per 10,000 person-years (PYs) for site-specific cancers of SLE patients were calculated using ICD-O-3 codes. Multivariable logistic regression analysis was utilized to assess the association between immunosuppressive agents and cancer development in SLE patients.

Results

A total of 10,013 predominantly female (91%) Korean SLE patients with a mean age of 3

SUBMITTER: Cho SK 

PROVIDER: S-EPMC11753053 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature