Do we underestimate risk of cardiovascular mortality due to lead exposure?

ABSTRACT:

Background

Studies using data from the National Health and Nutrition Examination Survey-III (NHANES-III) have demonstrated significant prospective associations between blood lead levels and increased mortality. Bone lead represents cumulative lead burden and thus is a better biomarker for assessing chronic impacts, but its in vivo assessment requires special K-x-ray fluorescence (KXRF) instrumentation. Our team recently developed an algorithm predicting bone lead levels from a combination of blood lead levels, age and other socioeconomic and behavioral variables. We examined the associations of our algorithm-estimated bone lead levels and mortality in NHANES-III.

Methods

We included 11,628 adults followed up to December 31, 2019. Estimated tibia lead and patella lead levels

SUBMITTER: Park SK 

PROVIDER: S-EPMC11753055 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature