Exploring sex differences in Alzheimer's disease: a comprehensive analysis of a large patient cohort from a memory unit.

ABSTRACT:

Background

Alzheimer's disease (AD) stands as the leading cause of dementia worldwide, and projections estimate over 150 million patients by 2050. AD prevalence is notably higher in women, nearly twice that of men, with discernible sex differences in certain risk factors. To enhance our understanding of how sex influences the characteristics of AD patients and its potential impact on the disease trajectory, we conducted a comprehensive analysis of demographic, clinical, cognitive, and genetic data from a sizable and well-characterized cohort of AD dementia patients at a memory clinic in Barcelona, Spain.

Methods

The study cohort comprised individuals with probable and possible AD dementia with a Clinical Dementia Rating (CDR) score between 1 and 3 diagnosed at the Memory Uni

SUBMITTER: Rosende-Roca M 

PROVIDER: S-EPMC11753069 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature