Clinical and Mycobacterium tuberculosis strain characteristics of tuberculosis patients with diabetes mellitus in Changping District, Beijing, China.

ABSTRACT:

Background

Diabetes mellitus (DM) is a major risk factor for tuberculosis (TB), However, limited research exists on their clinical and strain characteristics. This study aims to investigate the correlation between these factors in TB-DM patients in Changping District.  METHODS: Whole genome sequencing (WGS) and drug susceptibility tests (DST) were performed on culture-positive strains. Spearman correlation analysis was used to examine risk factors and the correlation between lineage, cavities, and hemoptysis in the TB-DM population. The specificity, sensitivity, and confidence intervals for predicting phenotypic drug resistance based on genotypic resistance were calculated.

Results

Among the 3924 TB patients, 292 had DM, showing a doubling in the proportion of TB patients wi

SUBMITTER: Cao X 

PROVIDER: S-EPMC11753084 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature