Efficacy and safety of gut microbiome-targeted treatment in patients with depression: a systematic review and meta-analysis.

ABSTRACT:

Background

The study aimed to comprehensively analyze and establish a framework for evaluating the efficacy of microbiome-targeted treatment (MTT) for depression.

Methods

We searched PubMed, Embase, Cochrane Library, Web of Science, and the Chinese National Knowledge Infrastructure database for randomized controlled trials (RCTs) on MTT in treating depression until October 19, 2023. A meta-analysis was conducted to evaluate the efficacy and safety of MTT. Comprehensive subgroup analyses were undertaken to explore factors influencing MTT's efficacy in treating depression. This study was registered with PROSPERO (CRD42023483649).

Results

The study selection process identified 51,570 studies, of which 34 met the inclusion criteria. The overall pooled estimates showed tha

SUBMITTER: Pan B 

PROVIDER: S-EPMC11753086 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature