MRI delta radiomics during chemoradiotherapy for prognostication in locally advanced cervical cancer.

ABSTRACT:

Background

Effective diagnostic tools for prompt identification of high-risk locally advanced cervical cancer (LACC) patients are needed to facilitate early, individualized treatment. The aim of this work was to assess temporal changes in tumor radiomics (delta radiomics) from T2-weighted imaging (T2WI) during concurrent chemoradiotherapy (CCRT) in LACC patients, and their association with progression-free survival (PFS). Furthermore, to develop, validate, and compare delta- and pretreatment radiomic signatures for prognostic modeling.

Methods

A total of 110 LACC patients undergoing CCRT with MRI at baseline and mid-treatment were divided into training (cohort_T: n = 73) and validation (cohort_V: n = 37) cohorts. Radiomic features were extracted from tumo

SUBMITTER: Wagner-Larsen KS 

PROVIDER: S-EPMC11753090 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature