Inherited metabolic diseases are a potent risk factor for cytomegalovirus infection in pediatric living donor liver transplantation.

ABSTRACT:

Background

Cytomegalovirus (CMV) is a major infectious complication in solid-organ transplant recipients, particularly in the context of pediatric liver transplantation. CMV serostatus is a well-established risk factor for postoperative CMV infection, with CMV seronegative recipients who receive organs from seropositive donors (D+/R-) being at the highest risk. Our previous research indicated a higher incidence of CMV infection in recipients with inherited metabolic diseases (IMDs) compared with those with biliary atresia (BA). This study aimed to determine whether IMDs constitute an independent risk factor for postoperative CMV infection.

Methods

We retrospectively analyzed data from 45 IMD and 230 BA recipients. We collected information on the occurrence and timing of epis

SUBMITTER: Ushijima K 

PROVIDER: S-EPMC11753104 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature