Hypervirulent Klebsiella pneumoniae have better clinical outcomes than classical Klebsiella pneumoniae for lower respiratory tract infection patients.

ABSTRACT:

Background

The clinical outcomes and microbiological features of lower respiratory tract infections (LRTIs) caused by hypervirulent Klebsiella pneumoniae (hvKp) and classical Klebsiella pneumoniae (cKp) have not been well understood.

Methods

This study collected 287 non-repetitive Klebsiella pneumoniae isolates from 287 LRTI patients. All these strains underwent annotation for resistance and virulence factors, with 141 strains undergoing mouse infection experiments to assess their virulence. The primary clinical outcomes of these patients were evaluated, including intensive care unit (ICU) admission and in-hospital mortality rates.

Results

A total of 46 capsule serotypes were identified. Among these isolates subjected to mouse infection experiments, the proportions of

SUBMITTER: Zhuo X 

PROVIDER: S-EPMC11753108 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature