Analytical sensitivity factors from distributions of time of flight of photons for near-infrared spectroscopy studies in multilayered turbid media.

ABSTRACT:

Significance

In the last years, time-resolved near-infrared spectroscopy (TD-NIRS) has gained increasing interest as a tool for studying tissue spectroscopy with commercial devices. Although it provides much more information than its continuous wave counterpart, accurate models interpreting the measured raw data in real time are still lacking.

Aim

We introduce an analytical model that can be integrated and used in TD-NIRS data processing software and toolkits in real time. This is based on the so-called sensitivity factors (SFs) of the distributions of time of flight (DTOFs) of photons measured in optically turbid and semi-infinite multilayered media, such as the human head.

Approach

We derived analytical expressions for the SFs that link changes in the absorption coe

SUBMITTER: Garcia HA 

PROVIDER: S-EPMC11753179 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature