Mapping subcortical brain lesions, behavioral and acoustic analysis for early assessment of subacute stroke patients with dysarthria.

ABSTRACT:

Introduction

Dysarthria is a motor speech disorder frequently associated with subcortical damage. However, the precise roles of the subcortical nuclei, particularly the basal ganglia and thalamus, in the speech production process remain poorly understood.

Methods

The present study aimed to better understand their roles by mapping neuroimaging, behavioral, and speech data obtained from subacute stroke patients with subcortical lesions. Multivariate lesion-symptom mapping and voxel-based morphometry methods were employed to correlate lesions in the basal ganglia and thalamus with speech production, with emphases on linguistic processing and articulation.

Results

The present findings revealed that the left thalamus and putamen are significantly correlated with concept pr

SUBMITTER: Liu J 

PROVIDER: S-EPMC11753205 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature