Lipopolysaccharide affects metabolic processes and energy homeostasis in the corpus luteum.

ABSTRACT:

Introduction

Chronic inflammation caused by Escherichia coli infections has a significant negative impact on the reproductive system and impairs fertility. The corpus luteum (CL) plays a central role not only in regulating the ovary cycle, but also in implantation of the embryo and maintenance of early pregnancy through the secretion of progesterone. Understanding the intricate interplay between inflammatory processes and reproductive organ's function is crucial for the development of effective therapeutic strategies to alleviate reproductive disorders and improve fertility.

Methods

The aim of this study was to determine the in vitro effects of lipopolysaccharide (LPS) on the proteomic profile of the porcine CL in the mid-luteal phase of the estrous cycle using LC-MS/

SUBMITTER: Mierzejewski K 

PROVIDER: S-EPMC11753227 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature