Modelling host-pathogen interactions: <i>Galleria mellonella</i> as a platform to study <i>Pseudomonas aeruginosa</i> response to host-imposed zinc starvation.

ABSTRACT: Nutritional immunity, a key component of the vertebrate innate immune response, involves the modulation of zinc availability to limit the growth of pathogens. Pseudomonas aeruginosa counteracts host-imposed zinc starvation through metabolic adaptations, including reprogramming of gene expression and activating efficient metal uptake systems. To unravel how zinc shortage contributes to the complexity of bacterial adaptation to the host environment, it is critical to use model systems that mimic fundamental features of P. aeruginosa-related diseases in humans. Among available animal models, Galleria mellonella has recently emerged as a promising alternative to mammalian hosts. This study aims to evaluate whether G. mellonella can recapitulate the zinc-related nutr

SUBMITTER: Michetti E 

PROVIDER: S-EPMC11753293 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature