Wall shear stress modulates metabolic pathways in endothelial cells.

ABSTRACT:

Introduction

Hemodynamic forces play a crucial role in modulating endothelial cell (EC) behavior, significantly influencing blood vessel responses. While traditional in vitro studies often explore ECs under static conditions, ECs are exposed to various hemodynamic forces in vivo. This study investigates how wall shear stress (WSS) influences EC metabolism, focusing on the interplay between WSS and key metabolic pathways.

Objectives

The aim of this study is to examine the effects of WSS on EC metabolism, specifically evaluating its impact on central carbon metabolism and glycolysis using transcriptomics and tracer metabolomics approaches.

Methods

ECs were exposed to WSS, and transcriptomic analysis was performed to assess gene expression changes related to metabolic pa

SUBMITTER: Simoes-Faria R 

PROVIDER: S-EPMC11753319 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature