Influence of Lens Power on IOL/Posterior Lens Capsule Interactions and IOL's PCO Potential.

ABSTRACT:

Purpose

Severely myopic eyes have been associated with high posterior capsule opacification (PCO) incidence. Although it has been reported that myopic eyes have weaker or more delayed capsule adhesion than emmetropic eyes, it is unclear whether/how dioptric power and posterior curvature of IOLs affect IOLs' affinity for the posterior lens capsule (PLC) and their PCO potential.

Methods

To investigate this, acrylic foldable IOLs with increasing dioptric power of 6.0D (for high myopia), 20.0D, and 30.0D (for low/non-myopia) were tested on their binding affinity toward PLC and their ability to inhibit the proliferation and infiltration of lens epithelial cells (LECs) using an in vitro simulated human PLC (sPLC) model.

Results

We found that IOL power and posterior radius o

SUBMITTER: Chatila A 

PROVIDER: S-EPMC11753477 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature