[¹⁸F]Trifluoroiodomethane - Enabling Photoredox-mediated Radical [¹⁸F]Trifluoromethylation for Positron Emission Tomography.

ABSTRACT: The development of new tracers for positron emission tomography (PET) is highly dependent on the available synthetic tools for their radiosynthesis. Herein, we present the radiosynthesis and application of [¹⁸F]trifluoroiodomethane - the first reagent for broad scope radical [¹⁸F]trifluoromethylation chemistry in high molar activity. CF₂ ¹⁸FI can be prepared from [¹⁸F]fluoroform with 67±5 % AY and >99 % RCP. Its synthetic utility is demonstrated by the radiosynthesis of previously unprecedented ¹⁸F-labeled α-trifluoromethyl ketones and ¹⁸F-labeled trifluoromethyl sulfides, important motifs that are present in a range of bioactive compounds. Both protocols are Ru- and photo-mediated and proceed under mild reaction

SUBMITTER: Veth L 

PROVIDER: S-EPMC11753608 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature