Protect or prevent? A practicable framework for the dilemmas of COVID-19 vaccine prioritization.

ABSTRACT: Determining COVID-19 vaccination strategies presents many challenges in light of limited vaccination capacity and the heterogeneity of affected communities. Who should be prioritized for early vaccination when different groups manifest different levels of risks and contact rates? Answering such questions often becomes computationally intractable given that network size can exceed millions. We obtain a framework to compute the optimal vaccination strategy within seconds to minutes from among all strategies, including highly dynamic ones that adjust vaccine allocation as often as required, and even with modest computation resources. We then determine the optimal strategy for a large range of parameter values representative of various US states, countries, and case studies including retiremen

SUBMITTER: Arghal R 

PROVIDER: S-EPMC11753641 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature