In vivo mapping of sodium homeostasis disturbances in individual ALS patients: A brain 23Na MRI study.

ABSTRACT:

Objective

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by significant heterogeneity among patients. 23Na MRI maps abnormal sodium homeostasis that reflects metabolic alterations and energetic failure contributing to the neurodegenerative process. In this study, we investigated disease severity at the individual level in ALS patients using brain 23Na MRI.

Methods

1H and 23Na brain MRI were collected prospectively from 28 ALS patients. Individual map of abnormal total sodium concentration (TSC) was computed using voxel-based statistical mapping for each patient compared to a local database of 62 healthy controls. Clinical data included the revised ALS functional rating scale (ALSFRS-R), ALSFRS-R slope, ALSFRS-R at 6-month and survival time.<

SUBMITTER: Grapperon AM 

PROVIDER: S-EPMC11753670 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature