Administration of antigenically distinct influenza viral particle combinations as an influenza vaccine strategy.

ABSTRACT: One approach for developing a more universal influenza vaccine is to elicit strong immune responses against canonically immunosubdominant epitopes in the surface exposed viral glycoproteins. While standard vaccines typically induce responses directed primarily against mutable epitopes in the hemagglutinin (HA) head domain, there are generally limited or variable responses directed against epitopes in the relatively more conserved HA stalk domain and neuraminidase (NA) proteins. Here we describe a vaccine approach that utilizes a combination of wildtype (WT) influenza virus particles along with virus particles engineered to display a trimerized HA stalk in place of the full-length HA protein to elicit both responses simultaneously. After initially generating the "headless" HA-containing vir

SUBMITTER: Zhu X 

PROVIDER: S-EPMC11753672 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature