Automated extracellular volume fraction measurement for diagnosis and prognostication in patients with light-chain cardiac amyloidosis.

ABSTRACT:

Aims

T1 mapping on cardiac magnetic resonance (CMR) imaging is useful for diagnosis and prognostication in patients with light-chain cardiac amyloidosis (AL-CA). We conducted this study to evaluate the performance of T1 mapping parameters, derived from artificial intelligence (AI)-automated segmentation, for detection of cardiac amyloidosis (CA) in patients with left ventricular hypertrophy (LVH) and their prognostic values in patients with AL-CA.

Methods and results

A total of 300 consecutive patients who underwent CMR for differential diagnosis of LVH were analyzed. CA was confirmed in 50 patients (39 with AL-CA and 11 with transthyretin amyloidosis), hypertrophic cardiomyopathy in 198, hypertensive heart disease in 47, and Fabry disease in 5. A semi-automated deep learnin

SUBMITTER: Hwang IC 

PROVIDER: S-EPMC11753688 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature